Mail Us

contact@liqomics.com

Call Us

(+49) 1575 660 9397

Work With Us

What our assay can do for you

We provide combined genotyping and MRD assays for research purposes across all cancers. Our particular expertise is in lymphomas and hematological cancers. Beyond our standard assays we can integrate individual, exploratory features in collaboration projects. Please contact us for more information.

Minimal Residual Disease

Genotyping

Bespoke Features

Medical Services

Typical sampling flow for individual patients

Step 1
Treatment start /
Patient enrollment

A blood sample is sent to Liqomics and analyzed to identify tumor variants in the circulating tumor DNA to genotype the tumor and identify variants to track over time for MRD detection.

Step 2
During Treatment

Blood samples are sent to Liqomics and the identified tumor variants identifying each tumor are used to track minimal residual disease (MRD) at extremely high accuracy.

Step 3
After Treatment /
Monitoring

Blood samples are sent to Liqomics for monitoring of patients in remission. An increase in MRD can trigger a new treatment much earlier than a radiological relapse.

Cancers we cover

We have a highly sensitive combined MRD and genotyping assay for all lymphomas readily available. Assays for solid tumors such as lung cancer, gynecological tumors or pancreatic cancer can easily be designed for individual projects, leveraging our unique platform. Specific genomic targets that are of interest for your project can easily be included. Please contact us for more information.

Lymphoma
 

Lung Cancer
 

Gynecological Tumors

Pancreatic Cancer

Other Cancers
 

What cancers do we cover

We have a highly sensitive combined MRD and genotyping assay for all lymphomas readily available. Assays for solid tumors such as lung cancer, gynecological tumors or pancreatic cancer can easily be designed for individual projects, leveraging our unique platform. Specific genomic targets that are of interest for your project can easily be included. Please contact us for more information.

Treatment start / Patient enrollment

Treatment start / Patient enrollment

A blood sample is sent to Liqomics and analyzed to identify tumor variants in the circulating tumor DNA to genotype the tumor and identify variants to track over time for MRD detection.

During Treatment

During Treatment

Blood samples are sent to Liqomics and the identified tumor variants identifying each tumor are used to track minimal residual disease (MRD) at extremely high accuracy.
 

After Treatment / Monitoring

After Treatment / Monitoring

Blood samples are sent to Liqomics for monitoring of patients in remission. An increase in MRD can trigger a new treatment much earlier than a radiological relapse.

What we can do for you if you are a
CRO or Pharmaceutical Company

Use MRD in your clinical trial design

Whether it is selecting patients for trial enrollment based on MRD status, using MRD as an exploratory endpoint or surrogate endpoint. Our test can help you to design better trials.

 

 

Understand the treatments you are testing in more detail

Our MRD assay allows you to understand how well patients are responding to the treatment you are testing with unprecedented sensitivity and specificity. While we do not aim to substitute imaging for response assessment, the depth of response to a given treatment can be better understood using our MRD test.

Understand resistance to the treatments you are testing

With our test, you can see the emergence of potential resistance mutations without another biopsy. This can help you to understand why a treatment is working or not working.

 

 

How We Work

Publications

Here are some publications from our early development showing applications in Hodgkin Lymphoma and CNS Lymphoma.

Heger et al

Entirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA. Blood (2024) 143 (6): 522–534.
(LINK: https://doi.org/10.1182/blood.2023022020 )

Sobesky et al

In-depth cell-free DNA sequencing reveals genomic landscape of Hodgkin’s lymphoma and facilitates ultrasensitive residual disease detection. Med (2021) 2 (10), 1171-1194.
(LINK: https://doi.org/10.1016/j.medj.2021.09.002 )

Best Healthcare

General Research Services

Whether you are working at an academic institution or in industry, if you plan to sequence cell-free DNA and analyze circulating tumor DNA please get in contact with us. We will work with you to design a project for your needs.

Our standard assays can be used for genotyping, MRD and relapse detection. Bespoke features can be added for individual projects.

Platform applicable to all cancers
 

MRD, genotyping & additional features possible

Detection of a few cancer DNA molecules per million (10-6)

Universal assay for all patients with a particular cancer or group of cancers